CLUSTAL W (1.83) multiple sequence alignment HadV1 MSGKPSRIDTSRVKVFAGVS------------------------------------------------------------ AfuTmV1 MSANPDIGVPE---T----------------------------------------------------------------- BbPmV1 MSVSTVTSEIAHVQV----------------------------------------------------------------- BdRV1 MTDFDPLQ------------------------------------------------------------------------ CcFV1 MTTADPAE-PDAR-G----------------------------------------------------------------- FrPmV1 MTSLATERRPAPP-A----------------------------------------------------------------- PdPmV1 MSSLGTSYRTSIPAL----------------------------------------------------------------- AspTmV1 MENAGDP---V---S----------------------------------------------------------------- CcV1 MASEASFV--TQP-D----------------------------------------------------------------- MoPmV1 MSSSLYDSASE---P----------------------------------------------------------------- PbTmV1 MSTQCFTDEFVHADE----------------------------------------------------------------- BbPmV2 MASTSVSPAADYEDQ----------------------------------------------------------------- SstRV1 MSDKLENLQLMG-EL----------------------------------------------------------------- PmTMV1 MSYSGSGAFCE---K----------------------------------------------------------------- PjPmV1 MSSLGTSYRCGPPSL----------------------------------------------------------------- CCV PMTV---------------------------------------------------------------------------- EBHSV NTDLFCGDP-I---D----------------------------------------------------------------- RHDV TSNFFCGEP-I---D----------------------------------------------------------------- FMCV LKSLDMTTSA-----------------------------------GPSYKVKKSEVFDSDFD----------------P- TCV AYCR---------------------------------------------------------------------------- N1V VTHLPH-------------------------------------------------------------------------- NV GGDKGHYA--GHEIV----------------------------------------------------------------- TV FNLEGKTTY----------------------------------------------------------------------- ASCV EGK----------------------------------------------------------------------------- SV MPTG---------------------------------------------------------------------------- SVCV FAS----------------------------------------------------------------------------- FCV IPKG---------------------------------------------------------------------------- VESV TGEPRT-------------------------------------------------------------------------- TAstV W------------------------------------------------------------------------------- ANV LGVQSGK------------------------------------------------------------------------- DAstV W------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV LK------------------------------------------------------------------------------ PAstV RPD----------------------------------------------------------------------------- BCV1 MDYLTSAFN----------------------------------------------RITHWFNVPSNLEYIGTFSLPPGIL CpCV1 MRFTEYILS-------------------------------------------GFKVLDSSMDRSRNYQFIGFD-KPESQP WCCV MDYLITAFN----------------------------------------------RITHWFLTPTNLEYIGSYSLPPGLL AhV MSTLLIPQD---------------------------------------------------------------------TI CrV1 MPSFSANPT---------------------------------------------------------------------YQ FpV1 MLANIRDYF---------------------------------------------------------------------HE CSpV1 MKFVNIY------------------------------------------------------------------------- PCV1 MVRGTLVGY-DY-TQFQGDLVKSTHRHPHVVHREIAT------------------------------------------- PCV2 MAIYRMLNGYVF-TAFGNDLEKLDQRHIHHIRREEAT------------------------------------------- AoV MDDSHLDPTQ--LENAIEESLLLDDSTLTPSAKVRGASYNVIPPQFSSPGLAEIARYGGYGT----------------YS DdV1 MEEFTQDPTL--HNVQAEESHSIDTLHLRDAKRGSSTSEDVLHKGYADPCLREVAKYGGYST----------------YS PsV-S MEDSPFDPTL--LDVAVEESHLVDDSPLTPSNRTRGASYGIISEKFSSPGLREIARYGGYSV----------------YS HadV1 -------------------------------------------------------------------------------- AfuTmV1 -LKLVV----------------------------------------------------------S--------------- BbPmV1 -ACRPV----------------------------------------------------------S--------------- BdRV1 ---VNF----------------------------------------------------------A--------------- CcFV1 -VVLVI----------------------------------------------------------R--------------- FrPmV1 -FSPGV----------------------------------------------------------V--------------- PdPmV1 -ATVVT----------------------------------------------------------S--------------- AspTmV1 -LRLAL----------------------------------------------------------S--------------- CcV1 -VHG-P----------------------------------------------------------R--------------- MoPmV1 -LTAVV----------------------------------------------------------V--------------- PbTmV1 -LVLPI----------------------------------------------------------G--------------- BbPmV2 -LEAVV----------------------------------------------------------V--------------- SstRV1 -SWGRR----------------------------------------------------------GAAETKPPMIEPEDVV PmTMV1 -PLAVV----------------------------------------------------------D--------------- PjPmV1 -ATIAT----------------------------------------------------------A--------------- CCV -------------------------------------------------------------------------------- EBHSV -YRGLV----------------------------------------------------------A--------------- RHDV -YRGIT----------------------------------------------------------A--------------- FMCV --------------------------------------------TEKYQATFFRDCKTLTA-N----------------- TCV -------------------------------------------------------------------------------- N1V -------------------------------------------------------------------------------- NV -RYG-S-------------------------------------------------------------------------- TV -------------------------------------------------------------------------------- ASCV -------------------------------------------------------------------------------- SV -------------------------------------------------------------------------------- SVCV -------------------------------------------------------------------------------- FCV -------------------------------------------------------------------------------- VESV -------------------------------------------------------------------------------- TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 R---------------------------------------------VNEVAISNHKKTLEH-SFN--------------- CpCV1 P---------------------------------------------ADATMHHAVQAPVKH-AMR--------------- WCCV R---------------------------------------------VNDVAVANHKATLDR-SFD--------------- AhV -------------------------------------------------------AHTFDE-AVA--------------- CrV1 T------------------------------------------------------LIDDIDFDVP--------------- FpV1 KLTRLLYDHKIFQSNSKDPDLTLEAHHSSDIERIYKSIHYDFNRS-PAPIDYEAQYQSIKH-ILE--------------- CSpV1 -------------------------------------------------------------------------------- PCV1 ----------------------------------------------TYVDQYAYEH------------------------ PCV2 ----------------------------------------------TYRDEFALKE------------------------ AoV --------------------------------------------GQSNTDPWVRVA------------------------ DdV1 --------------------------------------------SNSNTDPWIRET------------------------ PsV-S --------------------------------------------GQSNTDAWIRTT------------------------ HadV1 -------------------------------------------------------------------------------- AfuTmV1 G------------------------------------------------------------------------------- BbPmV1 E------------------------------------------------------------------------------- BdRV1 P------------------------------------------------------------------------------- CcFV1 E------------------------------------------------------------------------------- FrPmV1 K------------------------------------------------------------------------------- PdPmV1 D------------------------------------------------------------------------------- AspTmV1 A------------------------------------------------------------------------------- CcV1 T------------------------------------------------------------------------------- MoPmV1 E------------------------------------------------------------------------------- PbTmV1 E------------------------------------------------------------------------------- BbPmV2 A------------------------------------------------------------------------------- SstRV1 S------------------------------------------------------------------------------- PmTMV1 E------------------------------------------------------------------------------- PjPmV1 E------------------------------------------------------------------------------- CCV -------------------------------------------------------------------------------- EBHSV FR------------------------------------------------------------------------------ RHDV HR------------------------------------------------------------------------------ FMCV -------------------------------------------------------------------------------- TCV -------------------------------------------------------------------------------- N1V -------------------------------------------------------------------------------- NV -------------------------------------------------------------------------------- TV -------------------------------------------------------------------------------- ASCV -------------------------------------------------------------------------------- SV -------------------------------------------------------------------------------- SVCV -------------------------------------------------------------------------------- FCV -------------------------------------------------------------------------------- VESV -------------------------------------------------------------------------------- TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 -KYL---------------------------------------------------------------------------- CpCV1 -KIL---------------------------------------------------------------------------- WCCV -KYL---------------------------------------------------------------------------- AhV -SESNLRIDEVPENYLE----------RFIHPSEPENFEFYSLRDSDIPSKRIPKNGIQVFENLKYHTNSKDNLYKDQPS CrV1 -IAHPFS--------IINTDLQPVDDEETVHDLGSKDFEFYKVVSNDLPLNRAPSVGIESLPNIRYHNHSNDHRYRDQPP FpV1 -DKQSQQGF---------------------------PHEYYRLHESPIPDDRIPPSGIKLLP-FEYKSMNVVTATPEVPE CSpV1 -------------------------------------------------------------------------------- PCV1 ---------------------------------------------------------------IETFSS----------- PCV2 ---------------------------------------------------------------LMDLSP----------- AoV ---------------------------------------------------------------LKNFDR----------- DdV1 ---------------------------------------------------------------LKIHDR----------- PsV-S ---------------------------------------------------------------LKEFDR----------- HadV1 ------------------------------------PATSSLGWADIADIELGPVLQEGRAVSRGRHDMLKVAQGHVSEM AfuTmV1 -------------------------------------A---------------------P---S---NAPAPTASYVSDI BbPmV1 -------------------------------------M---------------------A---P---HLQRASQDTVQGA BdRV1 -------------------------------------R---------------------T---S---ATPQAVTDTIGEM CcFV1 -------------------------------------K---------------------K---L---SDRPVPAVVVEEQ FrPmV1 -------------------------------------E---------------------R-------SNRPVPVEFAERQ PdPmV1 -------------------------------------A---------------------L---G---AVGAAHPSKVSEM AspTmV1 -------------------------------------V---------------------D---K---VPPAPAPDYLAET CcV1 -------------------------------------S---------------------I-------AKGPVTIREAEAM MoPmV1 -------------------------------------R---------------------P---S---PGVAQVIADVPSL PbTmV1 -------------------------------------G---------------------E---A---LSACQIKAEACDI BbPmV2 -------------------------------------A---------------------V---P---PTGKELRAAIPEL SstRV1 -------------------------------------T---------------------A---W---GVGEAGAVEIADL PmTMV1 -------------------------------------T---------------------C---SK--LSADAAFLRAEEL PjPmV1 -------------------------------------T---------------------V---G---ALGATTVSKVTEM CCV -------------------------------------------------------------------------------- EBHSV -------------------------------------V---------------------A---G---VE----------- RHDV -------------------------------------L---------------------V---G---AE----------- FMCV -------------------------------------------------------------------------------- TCV -------------------------------------------------------------------------------- N1V -------------------------------------------------------------------------------- NV -------------------------------------------------------------------------------- TV -------------------------------------------------------------------VP----------- ASCV -------------------------------------------------------------------------------- SV -------------------------------------------------------------------------------- SVCV -------------------------------------------------------------------------------- FCV -------------------------------------------------------------------------------- VESV -------------------------------------------------------------------------------- TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 ---------------YAHEIKLITQDYRRSDIDEES-------------------------------------------- CpCV1 ---------------LHNEFVHITTKFKRSTIDDSS-------------------------------------------- WCCV ---------------YEHEINLITKEYRRSPIDEDS-------------------------------------------- AhV SGPSPMRGVANIIREYFPQYLDDLRTWCRPKSSDDS-------------------------------------------- CrV1 TGPPPMRGVHRIINDSFPQYLPYLKEWCRPKTSSDA-------------------------------------------- FpV1 SGFKIHPRIERLLRSKYPQYLQYVRKYTRPLGTTNA-------------------------------------------- CSpV1 -------------------------------------------------------------------------------- PCV1 -----------------LYPELILKGWSRSYYLPEKHLAAVLNYSM---------------------------------- PCV2 -----------------ILYEQFLEGWSRSYYEGSKHLQAIIQYGI---------------------------------- AoV -----------------NVYD-DVYGFTRKPEGTPG-------------------------------------------- DdV1 -----------------ETYE-DIWGKTRRPEGTPG-------------------------------------------- PsV-S -----------------SVYD-DIYGYTRRPTGTLG-------------------------------------------- HadV1 VKLAMSRPGKSQV--KSIGLNI--MDYRVVDEMKVS---VPDDTSLAVMQPNGRTRVGLRGHLLKCPSDLTAVRSFLQGV AfuTmV1 VSWYARRNLKGGL--LQVDHTMSFVVWPTSAPISVPVHGVTTGSDPVVTAPQARARAF-RLKSYADGDLLRELRQFDGAK BbPmV1 LKWVADKYSRGGV--RRRNLTVHLSGVRGRADDVVLIPSVIEANSVLPEAPVHRAPYV-DIGGDSADSRYEGLKGLDKVQ BdRV1 VSWSLGRGLRGGT--RLSDRVIAFQLD-DDRVAEVPVAGNCTGTEPTISAAHARARAF-RVKPLADGGLIAALREYDGTR CcFV1 LNQLLRVFARNTS--TPRVVRCTIPGVDGRQDGKVVLRHVPDGGTLTTSFRTTRADLV-RVSGT-EEEKLEKLRDMSSDA FrPmV1 VNRMLRRFARNTA--ETRDVKFSLPGAGGPGCGVITVRHVADQGVPVVSVRTVRADLT-RVSGS-EREKLEQLRVMDTPD PdPmV1 LIGYATRNLRSGL--TVRRHIIDVVGLGGAPDARVELTRVADNAPPTVTSSHQRARVF-FAKGTCDGDVLNSLRNSDGPV AspTmV1 ISWYARRALKGGM--LMLERSMTFVNDQNQPPVELTVKGVSTGSDPVIAAPQARARAF-RLKGLADGDLLNQLRNYDGVD CcV1 ANYILRRTAKGTV--DTRDVVMTMPGAGGLPDGKITLHHVSAPSPVPQSFRTTRAALT-RIAGT-EKEKLESLRRFDTPS MoPmV1 LQTAIDVCLRSGL--HRGSCDVVVTVGPQCVRQVFSAQRVPGRTPPHIATPHARAAAF-RLDGNTEAEKLASLRAYDEPR PbTmV1 VQWVTDRYARGGR--SRNDRQFTYVGMGDVQDGEFTVVGVPSEDGVLPSVPITRAPFI-PVRGNNQEQLLKGLESLDTGK BbPmV2 AALAVEHCLRSGL--TRGSHTFSFSIAGGGPDHSVTIDSVPSDGPPFVATPHAQADAV-LIEGANDTERLASLAAFDEAK SstRV1 VATCVGFLTTVAPRQRQRQLPFALSNVEGAPVVDVEFQAAA-SHVAMPEMPTTRARYF-RVPGKTPSEIWESLRARDERN PmTMV1 VKHVGNITLRGGL--FAVDRKFKIARAPGLALESVMVRSSVEGKIPPVVVPQLRASAF-RVKPRADGDLISRLREMDGVR PjPmV1 LTGYAARNLRAGL--TVRKHVMDIAGIGGVPDMRVQLTRTVDDSPPTVASSHQRARVF-FVKGTCDGDILKRLRDSDGPV CCV -------------------------------------------------------------------------------- EBHSV ------------------------------------------PRPPVSG------------------------------- RHDV ------------------------------------------PRPPVSG------------------------------- FMCV -------------------------------------------------------------------------------- TCV -------------------------------------------------------------------------------- N1V ------------------------------------------------G------------------------------- NV --------------------------------------------GPAL-------------------------------- TV ------------------------------------------NKTPPET------------------------------- ASCV -------------------------------------------------------------------------------- SV -------------------------------------------------------------------------------- SVCV -------------------------------------------------------------------------------- FCV -------------------------------------------------------------------------------- VESV ---------------------------------------------IMKG------------------------------- TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 --------------------------------------------------------------------ILA---DFFSGD CpCV1 --------------------------------------------------------------------ITE---AFFKGD WCCV --------------------------------------------------------------------ILE---DFFSGD AhV --------------------------------------------------------------------IFN---DFNHEQ CrV1 --------------------------------------------------------------------IFE---DFNQPQ FpV1 --------------------------------------------------------------------TVS---DFFKPQ CSpV1 -----------------------------------------------------------------------EIQRFDGQP PCV1 ------------------------------------------------------------------------------PN PCV2 ------------------------------------------------------------------------------PD AoV --------------------------------------------------------------------MYKSLFKFAEGR DdV1 --------------------------------------------------------------------MYKALGRFGGEK PsV-S --------------------------------------------------------------------MYGSLLKFSEGK HadV1 KDSV--AD---G----SN---RHVDWALELVEKSMRLKN-------------------PSMVL---DL-RQLPQAFVLPA AfuTmV1 -NAS--ELGPRAFVRDSHRLD-------AAVEKASKLTD-------------------PTFH---ISQ-YQLPHPYSFGG BbPmV1 -NKG--AKGGAEFERKSSRME-------GAIRKRGMLRN-------------------PSFQ---VCR-YQLPFSYGYKA BdRV1 -NES--DMAKRAFVRDSSRLA-------EAVKKAAMLKN-------------------PTIS---ISH-YQLPDPFSFGG CcFV1 -PAS---AKSRAMERDASRLD-------EAVQRASLLRN-------------------PSFR---IYG-LQRKTPLGFEG FrPmV1 -DVE---VKAKQMRRDSHRLD-------KAVELASALKN-------------------PSFR---IYT-LQRNRPLGFGA PdPmV1 -RG------SPGYVRDSHRLD-------AVVERTAKLRR-------------------PNVE---LSN-YQLTVPLGFGP AspTmV1 -NAS--DLGSRHFFRDSHRLD-------AAVRKAGGMRN-------------------PTMR---ISQ-YQLPHPFSFGG CcV1 -DEK---TSRRSFTRDSHRLD-------DAVLKAASLKD-------------------PSFR---IYP-LQRETPLSFGG MoPmV1 -PKP--RGYKTPFYRSSARLN-------ELAEAIGRMRN-------------------PSVR---ISQ-YQLPSAMSFGG PbTmV1 -QEK--SGKRGVFDRRAERLR-------GAVAKAAALKS-------------------PSFH---IMA-HQLPFTWGYRS BbPmV2 -PKG--RSRKLPFYRSSSRLA-------AAVAKASKMDR-------------------PNFK---ICS-YQLSKPFAFGG SstRV1 -AGAKRKSAGGPLVRDANLLG-------PAMVKRSAIEDAGGK---------------PSFD---IAW-MQNTVPFGFGA PmTMV1 -GEA--VNRKVPFYRSVARLE-------PAIGKAAALKN-------------------PSFR---ISE-FQLPRPFSFGG PjPmV1 -KG------APGFRRDSHRLD-------KAIEKASRCER-------------------PNIA---LSN-YQLKVPLGFGP CCV ---------------------------------TRYWVA-------------------PGME---FDE-QMPYQPGLVGS EBHSV ---------------------------------TRYAKV-------------------PGVP--E-EY-HTGYRPANLGR RHDV ---------------------------------TRYAKV-------------------PGVP--D-EY-KTGYRPANLGR FMCV -------------------------------------------------------------------------------- TCV --------------------------------------S-------------------VAHP--EKYA-WESYEPAPYGS N1V ---------------------------------TKYSIS-------------------PGMR--E-EAHKCTHQPASLGR NV -------STKTKFWRSS------------------------------------------PE----PLP-PGVYEPAYLGG TV ---------------------------------TQIWYT-------------------KYS---E-EV-NAEMHPPLVGT ASCV -------------------------------------------------------------------------------- SV ---------------------------------TRYHRS-------------------PAWP--EEQP-GETHAPAPFGA SVCV -------------------------------------------------------------------------------- FCV ---------------------------------TRLHVS-------------------PAHT--EDYQ-ECSHQPASLGS VESV ---------------------------------TRLHVS-------------------PAHV--DDYE-ECTHQPASLGA TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 V-EK--FE-VPF----DE----HVETGLRCMADAFRPPR-------------------LCRPAHI-LD-VKHGYPYKWN- CpCV1 L-PY--HK-VPK----DG----SYQRALAATMQVFAPQV-------------------PIKPVHY-CD-LRY-YPWKLR- WCCV L-PY--FE-IPF----DE----HVERGLECMAAAFRPPR-------------------PCRPAHI-LD-VKHGYPYKWN- AhV R-IT--QP---F----TE----ERERRLLPLIDHFLGIK-------------------PYDIVHY-CD-TRF-YPWKLS- CrV1 I-PS--IP---L----QH----SRKQKILKLVNHFMGVK-------------------PYDIVHF-CD-TRF-YPWDLS- FpV1 T-PS--QP---V----EP----TRINHVMSHVMKKMAIT-------------------PYLPLHF-VD-TQY-DKRPLA- CSpV1 -TRH--GIAPKKIFRSKYIPT-------GLVPRLKYWRD---VPSRAEMSKRIGKYFEDEFK---FYP-N---------- PCV1 V-PA--SQ---L----SQ---SLYRQAIESAKNGFISLP-------------------RVKAF----------------- PCV2 P-DP--GL---I----DN---DIYNKAGYVVLESLGSLP-------------------RVRAF----------------- AoV S-DF--RS---L----NRVQRKAMQAAISKTKKRFKLPY-------------------KSDPLDW-HA-I---------- DdV1 C-DF--DN---L----SDPQKSSMRRAIAKAKKAFKLPY-------------------KREPLDW-HE-V---------- PsV-S N-SF--AS---L----NRVQRKSMINAISKAKKAFKLPY-------------------QREPLDW-HE-V---------- HadV1 DTGRVEP--YLQSFVVPSINTLVGPWA--------RHVKGFRAKLVEEATL--GNYTRHDPAKL-RERVSRYCRERI--- AfuTmV1 GPPNPER--PLTAPLISAINKV-SQRT--------RDPVGYRKRAKESIDL--GDFTTHDPDTL-HPRFLEYVHERT--- BbPmV1 RRVTTER--HLLGPTLDALHRA-KRRP--------GYPQVVKDSLDEAVDL--GDYTTHDPDTL-HKRFLEYVHERV--- BdRV1 GPPEQER--PLRSLAAAAAHKA-ARYV--------PPHRRYLQHANEAINL--GDFTTHDPDTL-HPRFLEYVHERV--- CcFV1 APPPEGR--PLRAAANLMATRL-AAVGPPGPDGRPGVDEVYKSQMLEALAM--GDYTTHDPASL-HPRFLEYVHERV--- FrPmV1 SGPQLSR--PLKPSGLVMANQL-ASLGTDPSTGQPVVDQVYKRHVQEALEL--GSYTVHDPDTL-HPRFLEYVHERT--- PdPmV1 ENVGSER--PYRPVAQSQMRRV-YD-L--------VGDAGYRQRCEDAIDL--GDYTHHDPDLL-HPRFLEYVHERS--- AspTmV1 GDAPKER--PLTAPTIAAVNRV-AKYT--------RDKLAYKKRAMEAIDL--GDYTTHNPDTL-HPRFLEYVHERV--- CcV1 GPPGEER--PLKPTGLVTAGRM-AKAA--------GTDELYRREMATALKM--GDSTTHDPDSL-HPRFLEYVHERT--- MoPmV1 GPTTPER--PLRAPLLAAIDAT-QR-R--------HPNIGYAQRVGGAAEL--GDYTTHDPDSL-HPRFLNYVKERI--- PbTmV1 RAVTEER--GLTGQLLHTVRVM-TAMP--------GYPETAKASVREAIDL--GDFTEHNPDTL-PERFLEYVHERT--- BbPmV2 GPPPKDR--PLSALVLGASDVA-GR-T--------VRSLDYRSAMEEAASL--ADYTTHDPDTL-HPRFLEYVRERV--- SstRV1 RPAVPER--DLRPVVETAIERA-SRLP--------YAPPGYRARRREAAHL--GDFTTHDPVTL-SPRFLEYVKPRV--- PmTMV1 GPPNPER--PLIGPVIGAFRRA-AG-A--------VDMPAYGKAVTNAIDS--GDYTTHDPDTL-HPRFLEYVHERT--- PjPmV1 ETVGDER--PYRPVLVSQLRGV-YD-K--------VADTTYRIKSEEAIDL--GDYTHHDPDTL-HPRFLEYVHNRT--- CCV NDPRNPAP--LVTILTSGLAPY-TD---------------------------------PGP-DI-PPAEL---------- EBHSV GDPDSHCT--LMNIAVKNLQVY-QQ---------------------------------EPKLTK-VDTFI---------- RHDV SDPDSDKS--LMNIAVKNLQVY-QQ---------------------------------EPKLDK-VDEFI---------- FMCV -------------------------------------------------------------------------------- TCV ADPRPQLLT-QEKILAAQLDPY-LQ---------------------------------QPP-PL-HPIVV---------- N1V NDPRCNQT--QVAMVVKALTPY-TS---------------------------------APAIEK-LDPCM---------- NV KDPRVQNGPSLQQVLRDQ--------------------------------L--KPFADPRGRMP-EPGLLEAAVETV--- TV KDPRNPIP--TSEILSEMFKPY-LT---------------------------------PNPGRV-NQADL---------- ASCV -------------------------------------------------------------------------------- SV GDKRYTFS--QTEMLVNGLKPY-TE---------------------------------PTA-GV-PPQLL---------- SVCV -------------------------------------------------------------------------------- FCV GDPRCPKS--LTAIVVDSLKPY-CE---------------------------------NVE-GP-PHDVL---------- VESV GDPRCPIS--LTGIMVNNLQPY-TE---------------------------------ASP-GP-DTATL---------- TAstV -------------------------------------------------------------------------------- ANV --------------------------------------------------------------PL---------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV --------------------------------------------------------------VL---------------- BCV1 -VNAEPP--FSTDEYFL----------------------NQRKTFGEFIRM--HEYEHIDKADF-FRRHPN-TESHD--- CpCV1 -PSAELP--FTDDPALF----------------------K---------------------------RVQ--HAAER--- WCCV -VNAEPP--FSTDEYFL----------------------SQRKTFGEFIRM--HEYEHIDKEDF-FRRHPN-IESHD--- AhV -TRAD----------------------------------------------------YFHNHSRDRKAHAA-KSHPD--- CrV1 -KKAD----------------------------------------------------YFHNHSNARKRHAQ-TSHAS--- FpV1 -NGTG----------------------------------------------------YHN-------RRSH-EMNIHALF CSpV1 -----------------------------------------EEKLNEAVNIVQEKWITHYGTSL-N---VTSVSES---- PCV1 ----DVL--TEMDQVPFKSSSSAGY--------------------------------------------------NY--- PCV2 ----DVL--TELDSVHYEQSSSAGY--------------------------------------------------DY--- AoV -----------------------------------------------------GQFL---------RRDTA-AGATF--- DdV1 -----------------------------------------------------GGFL---------RRDTS-AGSTF--- PsV-S -----------------------------------------------------GRHF---------RRDTS-AGVSF--- HadV1 --------PE------FKGETARVVGLGISLLEEVKKRNCVKVQARRIEDLGVEDLDGLMRNGSAG-EYKYFGYRKRKEP AfuTmV1 --------RS------VDGPTDDAMRAAQTVFARLWRRKGCKVKARSLSDAQPDNLLAIIKKGSPG-EYRSLGAEDRRDP BbPmV1 --------EG------VSADTKTDFLVAVQVMWRVWSDAGVAAEARPFSDATPEGLDAMFTTGNAG-EYRKHGVESRRDP BdRV1 --------TA------VDDRTDRAMRVATTALSRLWADKFSPPAARGLSDIDPANLRPLLNNGSPG-EYRLLGAADRLDD CcFV1 --------TA------VPRRESLALAFAQKVMRRVWDRAGVTARARGFVDTIPDNLSKLLNPGSPG-EFSEFGIMDRKNT FrPmV1 --------IN------VPERDEKAARWAARVMESIWRSKGISVKARTYIDTEPDNLAELMNPGTAS-EYAEHGVHSRKDP PdPmV1 --------TD------VDQDTHVAVSEAMAVMAKHWVSKGLAVKARPLSDAVPEVFGTEITAGSQG-EYRALGATSRNDE AspTmV1 --------EK------VDGPTDEAMRAAQGVLLDMWGRLGNGVEARPLSDAAPDTLLGIIKKGSVG-EYRSLGAEDRRDP CcV1 --------RS------VPEKENKALAWAVTVMKELWRNQGIRAEARGIDSAEPDVLSSLMNPGSAG-EYAEMGATNRKDP MoPmV1 --------TS------VDERTTRAMDTAVDLQTTVWRDQGISVDARPLSDAEPAVLSTMVNRGSPG-EYRMFGVTDRRDP PbTmV1 --------PE------FDEELSPVFVTAAQVMHAVWDQAGIKAKARHFADINPATLDSLFTSGNAG-EYRLSGVESRRDP BbPmV2 --------TS------VDEPTTAAMTAAQAVQAQLWADSGIRVAARDLSDAAPEPLADIINHGSTG-EYRALGVSDRKDP SstRV1 --------EI------APPRTDVALRLASDIMIKVWQAAGIAPRARSVFDVDPEYLADIIKDGNAG-EYRTAGISSRRDP PmTMV1 --------TK------VDDDTAAFLSAAVNLRARMWKGKGIQARARPLSDAEPETLLPMIKKGSPG-EYRILGASNRRDK PjPmV1 --------TE------VDAITHESMREAKAVMAKHWSSLGLNVKARPLSDAVPEVFGAEITAGSQG-EYRVLGATSRNDE CCV -------------------------ALARAQVTAALQ-AL-----------------MGVEVSPNL-DFAAAWGSLNKDT EBHSV -------------------------ERAAADVLGFLR-FL-----------------TKGERQMNL-NFSAAFNVLDLST RHDV -------------------------ERAAADVLGYLR-FL-----------------TKGERQANL-NFKAAFNTLDLST FMCV -------------------------------------------------------------------------------- TCV -------------------------E-AASYVQRHLS-NL-----------------LSFCPAPAVESLPIAIKRLDLST N1V -------------------------VAAITEVRTAIQ-SL-----------------TPKGGFRPL-TFAAAWQSLDLST NV --------TS------MLE--------------------------------------QTMDTPSPW-SYADACQ------ TV -------------------------LAAAEAVRVKLN-AL-----------------VKTRIDL---SAQEAFETLDPST ASCV -------------------------------------------------------------------------------- SV -------------------------SRAVTHVRSYIE-TI-----------------IGTHRSPVL-TYHQACELLERTT SVCV ---------------------------------------------------------------------------LDQTT FCV -------------------------HRVQKMLIDHLS-GF-----------------VPMNISSET-SMLSAFHKLNHDT VESV -------------------------NRVSKMLTSHME-GY-----------------VPKVHKTEE-DSISAFYMLNHDT TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 ---LIRTIVPPKFGYLKSMIFSWT----R-RWHHIIKEGFTE-------------------------------------- CpCV1 ---KQIPDKRMSFGNLYNHIFEYL----R-PIIHYIKNGPFH-------------------------------------- WCCV ---FLRTVVPPKFGFLKSMIFSWT----R-RWHHIIKSGFQD-------------------------------------- AhV -----FATGPTKKSYFINSHLFFD----R-STVHNIKEYGFP-------------------------------------- CrV1 -----TATGPTKKSWFINAHLFHD----R-STVHNIKLYGLP-------------------------------------- FpV1 SHPKEYESKRTSKGYYVNAFLESA----R-SLIHWIKLYGNP-------------------------------------- CSpV1 ------------------------------------------------------------------------FRTLPKST PCV1 --------TGRKGL-IGDENHSRAISIAKAVLWSAIKDDGEG-------------------------------------- PCV2 --------HGPKGP-IQGENHIRAITRAKATLWSAIKDEGEG-------------------------------------- AoV --------MGCKKGEVMEDIYHEA----R-WLAHRMKQDGSQ-------------------------------------- DdV1 --------MGTKKGDVMEEIYHEA----R-WLGHVMKQDGRK-------------------------------------- PsV-S --------MGQKKGDVMEEIYHEA----R-WLGHRMKQNGRA-------------------------------------- HadV1 ELMGML---------------------HNTIVNFLPAARAF---M-RT--GKYPIGRLYPEVLTIL-FGKKET-VSDKM- AfuTmV1 RLIATM---------------------SSSLLRYASAGVQV---A-RG--RPPPGWVDTTTQVTLT-FGKREP-KAAKI- BbPmV1 RALDML---------------------SKHVQGFTVAGRNM---P-TG--MSPPAFVDRLDHVTTS-FGKREP-KKAKI- BdRV1 RLVDTM---------------------AASLARYSSAANAT---L-KT--GRVPTWIETTTQPVLT-FGKKEP-KAXKM- CcFV1 RLLSTM---------------------SRSLERFFIAGQAH---A-RQ--RPVAPWVNFTQQPVMS-FGKTEL-KAAKM- FrPmV1 RLIETL---------------------SQDLKRMYKAGYSH---A-HG--RPMPSWVYFSQQPVLS-FGKTEL-KQAKV- PdPmV1 RLVLTL---------------------CDSLLRYGEAARQV---V-RA--GRVPDFVNTTQQPSGM-FGKNER-RAAKY- AspTmV1 RLVATM---------------------SSSLMRYGRAGAAV---A-AG--RPYPGWVDTTMQPSLS-FGKREP-KAAKV- CcV1 EVLELL---------------------SKSIKRYYKAGHAM---A-TR--GRRAPWADFTQQPVMS-FGKKEA-KAAKL- MoPmV1 RLVKLM---------------------SDSILRYGAAGRRV---A-AG--KRPPPWVATTIQPTLT-FGKEEP-KAAKL- PbTmV1 RMLEML---------------------SGHLQRFQSAGRSV---F-NG--RAVPSWVDTIDHVVTS-FGKTEA-KAAKM- BbPmV2 RLVSLM---------------------SQSLLRYGVVGRLA---L-AG--KRPPRWVATTLQPTLS-FGKEEP-KAAKRD SstRV1 RMMHML---------------------SDHITGFVHAGREL---M-AG--RTVPSYLGTLQHQTLS-FGKEEA-KAAKP- PmTMV1 RLVATM---------------------SASLLRYAEVGKRV---G-RG--LRPPAWVGTTMQPTLQ-FGKEEP-KARKL- PjPmV1 RLVLTL---------------------CDSLLRYGEAGRQA---V-RS--GRLPDFVHTTQQPSGM-FGKNER-KAAKY- CCV SCGPLV-PGKKRDYMDEAG-NL----LPGTLRDHLSTSWGI---A-TT--GKA---LRHI---YAL-ALKDELLPRRKI- EBHSV SCGPFV-PGKKIDHVKDGK-------LDEVLSKHLYKCWSV---A-NS--GKA---LHHV---YAC-GLKDELRPLDKV- RHDV SCGPFV-PGKKIDHVKDGV-------MDQVLAKHLYKCWSV---A-NS--GKA---LHHI---YAC-GLKDELRPLDKV- FMCV ------------------------------------------------------CEIVI---KDEM-RK------ISK-- TCV SCGPFV-PGTKSDYFISTA-SGPMLKPGTEMTRHLDCTVAI---A-ST--GRP---ICHA---YQL-ALKDELLPERKI- N1V SAGALA-PGKTKRDLCDPDTGM----PAGKYREMLLAAWSR---A-GT--GTP---LDHT---YIV-ALKDELRPVEKV- NV -----------------------------SLDKTTSSGYPH---H--K--RKNDDWNGTTF--VGE-LGEQAA-HANNM- TV SSGYPL-YCKKDRSLP-GV-EA----TITR------VQNWL---D-GK--GQL---HRPI---YTA-ALKDEPVKQSKI- ASCV ------------------------------------------------------CRVSL---KDEL-RP------EVK-- SV SCGPFV-QGLKGDYWDEEQ-QQ----YTGVLANHLEQAWDK---A-NK--GIA---PRNA---YKL-ALKDELRPIEKN- SVCV SSGYPN-YTNKDPTRA-HI-QA----TRAR------VEDFM---Q-GK--GEL---HPPV---YTA-ALKDEPYLLEKV- FCV SCGPYL-GGRKKDHMANGE-------PDKQLLDLLSAKWKL---A-TQ--GIA---LPHE---YTI-GLKDELRPVEKV- VESV LCGPYI-GARKKDHVKDGV-------LDKNLLDLLSSKWNR---A-KL--GLA---LPHE---YAL-GLKDELRPKDKV- TAstV ----------------------------------------------------------------WC-FLKTEVLKLAKI- ANV ---------------------------------------------------------------WWC-FLKNEILKEKKV- DAstV ----------------------------------------------------------------WC-FLKNETLKVSKV- HAstV -------------------------------------------------------------------------------- FAstV ---------------------------------------------------------------------------KEKI- PAstV ---------------------------------------------------------------WYL-FLKKEIIKEEKI- BCV1 -------------------------------------STGL---H-TT--GYFYNRFIF---PMLL-HTKTAI--VKQ-- CpCV1 -------------------------------------L-PF-----KT--SWPQDDYLT---PMRS-HARSAI--QPI-- WCCV -------------------------------------STDL---E-QT--GYFFNRFIF---PMLL-HTKTAI--VKK-- AhV -------------------------------------F-RPTTDSARNETLLDLWFKKV---PTEL-LVRSH---ISK-- CrV1 -------------------------------------F-KPHSYAARNKILQELWFKKI---PTEL-LVRSH---ISN-- FpV1 -------------------------------------F-RHCPSDLAQ--SLREFFLQR---PTML-FTRNH---ISDR- CSpV1 SAGLPFKSGCTKYEARNK------------MMRLARSQWDRV----SK--GSQ---LQVL--PCRS-GARCQ---LRK-- PCV1 --------------------------------------------------IEHVIRTSV---PDVG-YTRTQL--TDL-- PCV2 --------------------------------------------------IEHVIRSAV---PDVG-YTRTQL--TDL-- AoV --------------------------------------------------RFNPKQMRF---PPCLAGQRGG---MSE-- DdV1 --------------------------------------------------GFDPTKMRF---PPCLAGQRGG---MSD-- PsV-S --------------------------------------------------KFDPSKMRF---PPCLAGQRGG---MSE-- HadV1 V-N----------------G--------------------VREEKVQRCIFDGPPNPYAIGAFLYGDLIDSFKKG--DPT AfuTmV1 V-D----------------G--------------------VRQAPVPRFIFNLSPVNYALASFLHYDISHFLMDNDPTHG BbPmV1 V-N----------------G--------------------QRVAPVPRFIFNPSPCSYAMGAFLHSDISHALQDRDPLHG BdRV1 R-G----------------G--------------------ERVAPVPRLIFNVSPINYALAVFLHGDLSKKLQEFDPTHG CcFV1 V-D----------------G--------------------RRAAPVPRFIFNLSPINYCLAAFLHSDLSHSLRERDPTHG FrPmV1 V-N----------------G--------------------KREEPVPRFIFSPSPNNYKTGAYLHSDASHKLQELDPTHG PdPmV1 K-D----------------G--------------------RRVEPVPRCIFNVSPVDWALAKFLHGHISEFLSEHDTLHG AspTmV1 K-D----------------G--------------------KRVAPVPRFIFNVSPINYALGSFLHYDLSHFLQERDPTHG CcV1 V-N----------------G--------------------VRTPPVPRFIFNPSPVNYALAAFLHGDLSHQLQTRDPTHG MoPmV1 E-N----------------G--------------------VRVPPVPRFIFNLSPANYGPAAFLHSDLSHELQEKDFTHG PbTmV1 V-D----------------G--------------------VRVPPVPRFIFNPSPCQYSAGAFLHSDMSKLLQKHDPTHG BbPmV2 E-D----------------G--------------------RKVPPIPRFIFNLSPVNYALAAFLHSDISHQLQDRDPTHG SstRV1 V-PAHPGDDGAYLRPDGTWA--------------------TRVAPIPRFIFSPSPCNYAVAAFLHHDVSKSMMDLDPTHG PmTMV1 K-D----------------G--------------------KWVPPIPRFIFNPSPVNYALATFLHGDLSHELQLKDPAHG PjPmV1 K-E----------------G--------------------ERVTPVPRCIFNVSPVDWTLAKFLHGHLSEFLSENDPLHG CCV Y-----------------------------------------ETPKKRLLWGCDAGVALAAAGVFQPVYERIKSTAAWGP EBHSV K------------------------------------------EGKKRLLWGCNVGVALCAAAVFHNLCFKLKTVARFGP RHDV K------------------------------------------EGKKRLLWGCDVGVAVCAAAVFHNICYKLKMVARFGP FMCV -----------------------------------------IETCSSRLIFSFDVGQVVQAKQYVGSIQKQLIDSVGEHF TCV K------------------------------------------ESRKRLLWGTDVGLTTLAAMVWGQLLDNLKSVVVASP N1V A------------------------------------------EGKRRLIWGADARVALIASAALTPVANALKTVTNLLP NV YEN----------------AKHMKPIYTAALKDELVKPEKIYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHVIKLP TV D------------------------------------------DGKKRLLWCAPLETSIACAALMTDICAQLKIMRGEWP ASCV -----------------------------------------RQKGLTRPIFCFDVHDTVRVKSSIGPGLQHLADTCGVHI SV K------------------------------------------AGKRRLLWGCDAATTLIATAAFKAVATRLQVVTPMTP SVCV A------------------------------------------AGKRRLLFCSPFETTMACARVFGPVTEALKSVRLRWP FCV S------------------------------------------EGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGP VESV A------------------------------------------VGKRRLIWGCDVGVSTVCAAAFKRVSESIMANHALGF TAstV E------------------------------------------QDDIRMILCTDPVFTRIGAAFEQHQNSLMKLETENHH ANV S------------------------------------------EDDIRIITCSDPVITRLGASFDSEQNERMKERTETHH DAstV K------------------------------------------NNDIRMILCTDPVYTRIGATFEQDQNARMKQQTETRA HAstV -----------------------------------------------RQIVCADPIYTRIGACLEAHQNALMKQHTDTSV FAstV K------------------------------------------DSDIRQIICPDAIYSRIGAALEQHQNNLMKKHTEDSS PAstV K------------------------------------------DNDIRQIVCADPIYTRIGASLEAHQNQLMKQRTRTSV BCV1 -----------------------------------------DDPNKMRTIWGASKPWIIAETMLYWEYIAWIKLNPSVTP CpCV1 -----------------------------------------SDPNKVRFVYGYPKVGIFPQAMFFWPLFVYYH-ITGQSP WCCV -----------------------------------------NDPNKMRTIWGASKPWIIAETMFYWEYLAWIKHNPGATP AhV -----------------------------------------RDNLKVRPVYNAPMIYIRIECMLFYPLLAQARKR--DCC CrV1 -----------------------------------------PKKLKVRPVNNAPMIFLRIECMLFYPLLAQLRKQ--QCS FpV1 -----------------------------------------DGILKQRPVYAVDDLFLTIESMLTFPAHVIARKP--ECC CSpV1 -----------------------------------------RGENKPRLIWAYPGYLSIIENQYLT----AIKKVPPPNF PCV1 -----------------------------------------LEKTKVRQVWGRAFHYILLEGLVAYPFIQTVMSH--KTF PCV2 -----------------------------------------YEKTKIRGVWGRAFHYILLEGTIANPLLDVFKRG--GTF AoV -----------------------------------------ASDPKTRLVWIYPAEMLVIEGQ-YAPTMYHKFMADPNTP DdV1 -----------------------------------------RTDPKTRLVWIYPAEMLVVEGF-YAPLMYHDYMNDPKSP PsV-S -----------------------------------------ASDPKTRLVWIYPAEMLAIEGF-YAPEMYHAYMDDPLSP * : HadV1 FGPGMGKARKKDRKVQEFLYRSFPSG----VESKFDMIMADIKHWDTALVEAMIYGILDM-YERLVDKSNLGP------- AfuTmV1 --PGFGPGRGRARKFMDLVERAFDGR--FSTPDGARLIMSDITKWDANMCEALIKYSIDL-LEDAVDKSALSP------- BbPmV1 --PGFGPGRGRAVKFTRIVEAACPDG--SRLRGGCKAVMSDIEKWDANMSEFLIGTSFDA-LEAFVDKSKLAP------- BdRV1 --PGFGPGRGRATVFLDLLERAAGGG--V-FNRAGAFSMSDIEKWDANMCEALMGYAFDL-LESAVDTSQLTD------- CcFV1 --PGFGPARGRAGKLLSKVESQLAG----VGKLRTRAIMSDIAKWDANMCEVLISASFDL-IESAVDKTGLDA------- FrPmV1 --PGFGPSRGRAHKLLDKVMKHLIPG---TTKLSHRAIMSDIAKWDANMPEFLLGLAFDS-LESIVDKSDLDS------- PdPmV1 --PGYGPNRGRSWKLLRVLDRAFGAS----TTAEHNVIMSDIEKWDANMSEYLLGRAFDL-LESAVDCSGLNE------- AspTmV1 --PGFGPGRGRAAKFLGLLDDVTGSG--YTTRDGARLIMSDIYKWDANMVEALLGYAFDV-IEDGVSKLGLDT------- CcV1 --PGFGPGRGKAWKFLDKVAAHLLPG---KAELSCKAIMSDIAKWDANMSEALLSATFDL-MESVVDKSSLDA------- MoPmV1 --PGFGPGRGRSGKFLDIVNRSFGAG--VSVPGDERLVMSDIDKWDGNVREALGYPTYDA-LESAVNKSHLPA------- PbTmV1 --PGFGPGRGHARKFLKIAERACPQG--TTLRDGCQAIMSDIQKWDANMSEALLVAAFWC-LESFVDVTDLSG------- BbPmV2 --PGFGPGRGRSGKFLNVVRRAFGNS--CLLPEGESMVMSDILKWDASVVEALAQPAFDS-LERAVDTRGLSP------- SstRV1 --PGFGPGRGRSHKFTDLVTRSFGDK---NVMVDDEMVMSDIEKWDASATEALLGCGMDT-MERAVGKEHLTD------- PmTMV1 --PGFGPGRGRAHAFTSLIEKCFGDR--TETPDGEALVMSDIEKWDANFPEVLIGAVMDM-IEAAVDVSHLSR------- PjPmV1 --PGYGPNRGRAWKLLRLLDKAYGEE---TVNGTFRLSMSDIEKWDANMCEYLLVHAFDL-LESAVDCSGLSA------- CCV ISVGICLERPEVFNAFQ-------------HRFTGPVSCLDYSGWDSTMHHAVITAAVEI-LSVFAEDTPLTH------- EBHSV IAVGIDMTSRDVDVMIT--------Q---LTSKAGDFLCLDYSKWDSTMSPCVVRLAIDI-LADCCEQTELTK------- RHDV IAVGVDMTSRDVDVIIN--------N---LTSKASDFLCLDYSKWDSTMSPCVVRLAIDI-LADCCEQTELTK------- FMCV SAVGISYMAGTWS----SV----ASK----LKQYEHHIDADFAAWDKSMSSTMLTSVVRV-YTSPIDDL----------- TCV ISVGCQMDSTFTATIIS-------------QVTDKHTLCLDYKKWDSTMHPEVIRLAINI-LCDMVPDTPFTE------- N1V IQVGVDPSSANCVSSWV--------G---RLQRHDHCLELDYSKWDSTMSPVIINIAIDI-LCNTCGSDSLRM------- NV IKVGMNTIEDGPL-I--------Y-A---EHAKYKNHFDADYTAWDSTQNRQIMTESFSI-MSRLTASPELA-------- TV GKVGMNPTVEW-WFLD--------------QQFGPNVLCVDYSRWDSTMIQSIYEIGVKT-LFGLSNHPKAP-------- ASCV WSVGISQQNGTWA----QV----CQR----LSKWRYVMDADFGRWDSTNSHPLLRQAAEV-LAVLAPED----------- SV VAVGINMDSVQMQVMND-------------SLKGGVLYCLDYSKWDSTQNPAVTAASLAI-LERFAEPHPIVS------- SVCV GCVGVKPAVEW-AFLVH--------H---LEMDGTLTYCADYSRWDSTLPRWLLKRALWV-MTKLSTFSRAH-------- FCV IQVGINMDSPSVEALFQ--------R----IKSAAKVFAVDYSKWDSTQSPRVSAASIDI-LRYFSDRSPIVD------- VESV IQVGINMDGPAVEDLFK--------R---LERPKHDRYCVDYSKWDSTQPPKVTSQSIDI-LRHFTDKSPIVD------- TAstV AQVGWSPFFGGIHRRAT-------RL---Y-GEHRYYVELDWTRFDGTIPPELFRRIKLM-RFFLLDPKYKT-------- ANV AQVGWTPFFGGLDKRVR-------RI---TSCGRTQVLELDWTRFDGTIPVQLFQRMREL-RKFFLTRRSR--------- DAstV AQVGWTPFFGGINRRVQ-------RL---MKIKNPQFVEMDWTRFDGTIPKALFYRIRQM-RFFFLRDEDKT-------- HAstV GQCGWSPMEGGFKKTMQ-------RL---VNKGNKHFIEFDWTRYDGTIPPALFKHIKEI-RWNFINKDQR--------- FAstV GQCGWTPFYGGFERKMR-------RL------DRNKIIEFDWTRFDGTIPRALFKHIKDL-RWEKMNKTHR--------- PAstV GQCGWTPMQGGFKAIME-------RL---VSKGNSYFVEMDWTRYDGTIPTELFRHIKEL-RWKLINKEQR--------- BCV1 MLWGYETFTGGWF----RL----NRDLF-CGFLQRSFLTLDWSRFDKRAYFPLLRRILYT-ARTFLTFDEGYVPTHSAPT CpCV1 LLWGYETMTGGWY----RL----NHELRSTPGISGSILELDWQGFDIHALFEVFDDIKNL-SWSFFDCSHGYQPTKDYQ- WCCV MLWGYETFTGGWF----RL----NHELF-CGLIQRSFLTLDWSRFDKRAYFPLLRRILYT-VKTFLTFEEGYVPTHAAPT AhV IMYGLETIRGGMN----EL----ERI----SNAFNSFLLIDWSRFDHLAPFTISNFFFKKWLPTKILIDHGYAQISNYHD CrV1 IMYGLETIRGGMM----EI----ESL----ATRFSNFMMIDWSKFDQTVPFTLVDMFYQDWIPTLILVDSGYAKIHNYND FpV1 IMYGLETIRGSNQ----IL----DKI----ASDYKSFFTIDWSGFDQRLPWVIVKLFFTEYIPRLLVVNHGYAPTYEYPS CSpV1 IGWSINWLDGG-KSLNRLL----FGD----KWTWQSIAQIDFSSFDATVRTELIFHAFKI-LRSLFDLTRTEN------- PCV1 IHAGQDPLI----SVPRLL----SDV----ALNCKWIYSLDWSQFDATVSRFEIHAAFDI-IKSYVDFPNYET------- PCV2 YHIGENPQY----SVPDIL----SQV----SECCKYLVAIDWSNFDATVARFEINMAFDL-IKTLIMFPNIET------- AoV MLNGRSSTRLYT-----DW----IND----AKEGDKLYGLDFSSFDSKVPSWLIRVAFNI-LRQNINFETWNG------- DdV1 MLNGKSAQRLYT-----EW----CCG----LRDGETLYGIDFSAFDSKVPAWLIRVAFDI-VKQNINFETFEG------- PsV-S MLNGKSSQRLYT-----EW----TCG----LRDGEMLYGLDFSGFDTKVPAWLIRVAFDI-LRQNIRWDSFRG------- . * :* HadV1 -----------------------D------EKIARQWLVELNAHYLIDKHVAHPSGFV-FLMKGCMGSGSFFTSPVNTDA AfuTmV1 -----------------------E------GLATRGLMYRVARRQLLEKLVEHPAGYF-VKLYGCMPSGSFYTSLVNTTG BbPmV1 -----------------------L------DRASREASCRYMRRTLMEKLVEHPSGYL-VHLYGCMPSGSFYTSLLNTVA BdRV1 -----------------------H------ARATRALMVRVARRQLMEKLVEHPSGYL-VWLSGCMPSGSYYTSLINTIG CcFV1 -----------------------T------ARATRKLMCMTAKRQLMQKIVEHPSGFF-VELFGCMPSGSYYTSMLNTVA FrPmV1 -----------------------H------ARAARKIMCRIARRQLMSKIVEHPSGYF-VELFGCMPSGSFYTSLLNTIG PdPmV1 -----------------------Y------NKAARASMVSVARRHLMEKLVEHPSGYF-VHMYGCMPSGSYYTSLLNTVG AspTmV1 -----------------------R------ALATRALMVKVARRQLMEKLVEHPAGYF-VRLFGCMPSGSFYTSLVNTTG CcV1 -----------------------T------GRATRRIMADVAKRQLMVKLIEHPSGYL-LELFGCMPSGSFYTSCVNTIG MoPmV1 -----------------------D------EAAARSLLSGVARRQLMEKLVEHPSGYL-LDMYGSMPSGSYYTSLVNTNA PbTmV1 -----------------------P------DRAARQMMCRYVERTLREKVLEHPAGYL-VKMFGCMPSGSFYTSLLNTIA BbPmV2 -----------------------A------ARAARSAMVGVARRQLTEKLLEHPSGYL-LMLYGTMPSGSYYTSLINTNA SstRV1 -----------------------L------DRSTRLAMYKYAKRTLLTKIVEHPSGYN-LVLHGTMPSGSYYTSLVNTVC PmTMV1 -----------------------D------ALATRRAMFSVSKRQLLEKLLEHPSGYL-VHLYGCMPSGSFYTSFVNTEG PjPmV1 -----------------------Y------NKAARAAMVSVARRHLLEKLVEHPSGYF-VHMYGCMPSGSYYTSLLNTIG CCV -----------------------S-----------------VVSTLTSPAIGCFMGCE-VTVKRGLPSGQPGTSMINSVC EBHSV -----------------------S-----------------VVLTLKSLPMTVLDAMI-VPTKRGLPSGMPFTSVINSIC RHDV -----------------------S-----------------VVLTLKSHPMTILDAMI-VQTKRGLPSGMPFTSVINSIC FMCV --------------------------------------DERTKARKLLDYMSHANTQF-GTTRQGLPSGMPCTSHLNSIA TCV -----------------------S-----------------LRATLCSPPVGYFMDKK-VTALRGLPSGMPGTSVVNSVC N1V -----------------------A-----------------VAQTLKSRPTALVEGVS-VPTKSGLPSGMPFTSQINSIV NV ---------------------------------------EVVAQDLLAPSEMDVGDYV-IRVKEGLPSGFPCTSQVNSIN TV -----------------------E-----------------LIDLLCQPRKVIVNDEL-RTVYQGLPSGIPTTSLLNCVC ASCV --------------------------------------HRVEVRQDLQKLIV-AETQF-GPTRTGLPSGLVCTAQMNCTS SV -----------------------C-----------------AIEALSSPAEGYVNDIK-FVTRGGLPSGMPFTSVVNSIN SVCV -----------------------E-----------------FVNFLSQPRWVICGAKK-FLVEKGLPSGIPMTSILNCVA FCV -----------------------S-----------------ASNTLKSPPVAIFNGVA-VKVSSGLPSGMPLTSVINSLN VESV -----------------------S-----------------ACATLKSNPIGIFNGVA-FKVAGGLPSGMPLTSIINSLN TAstV --------------------------------PENRDRYNWYVENLIDKVVLLPTGEV-CKIYGGNPSGQFSTTVDNNFV ANV --------------------------------RRYGKLLDWYNAQLTDRITLLPTGEV-THVKKGNPSGQFSTTVDNNLV DAstV --------------------------------PERKELYNWYVKNLLEKIILLPTGEV-CQARKGNPSGQFSTTVDNNMV HAstV --------------------------------EKYRHVHEWYVDNLLNRHVLLPSGEV-TLQTRGNPSGQFSTTMDNNMV FAstV --------------------------------ERYRHVHDWYVENLLTRYVLMPSGEV-TIQRRGNPSGQISTTMDNNMI PAstV --------------------------------EKYAEVHKWYVDNLLNRYVLLPSGEV-TLQTRGNPSGQFSTTMDNNMI BCV1 H----------------------PQWD-HTKAIRLERLWLWTLENLFEAPIILPDGRMYRRHFAGIPSGLFITQLLDSWY CpCV1 -------------------------GT-SCDPDRLKNLWEWIWFSIKYTPIRLPDGRLFRRSWRGVPSGLFITQWLDSVY WCCV H----------------------PQWS-QENIDRLERLWLWTLENLFEAPIILPDGRMYRRHFAGIPSGLFITQLLDSWY AhV HVHSFSAQAQSHGIPMISKEYQTPPEA-TVFAKKVLNLISFLERWYRDMVFVTPDGFAYRRTHAGVPSGILMTQFIDSFV CrV1 HVHSFAAQARKLGVHGNSNLNEAPPET-AIFANKVENLLKFINTWFKEMVYITPDGFAYRRTFAGVPSGILCTQLIDSFV FpV1 Y----------------------PDLTTNDMVSRLTNLITFLATWYFNMVFVTADGFSYVREHAGVPSGMLNTQFLDSFG CSpV1 ------------------------------------IMLDQLRHYFINTPILFYDK-I-IVKNRGIPSGSAFTQIIGTIV PCV1 -----------------------E------------QAFEITRQLFIHKKVAVPDGYI-YESHKGIPSGSYYTSLVGSII PCV2 -----------------------E------------LCFEICRQLFIHKKIAAPDGNI-YWSRKGIPSGSYFTSIIGSIV AoV -----------------------QPVSK-RDRQKWRNVWDAMVYYFINTPILMPDGRM-FRKYRGVPSGSWWTQMVDSVV DdV1 -----------------------KPVDK-HDAQKWSNVWEAMVWYFINTPILMPDGRM-FRKYRGVPSGSWWTQIIDSVV PsV-S -----------------------EKVSK-RDAQKWRNVWDGMVWYFINTPILMPDGRM-FRKYRGVPSGSWFTQMIDSVV ** * . HadV1 NSAYFFSHCFYSSGVA-SL-----SPHFVDVAGMSVRSNGDNQLASSELLE-LMG--GTYKLE-KHKEFLARVGMEM-KA AfuTmV1 NNLLVIGHAIARAVEETSLTHHGAAELLADAVDGTLISYGDNQLFSEHLFS-VLG--LAYDPE-KHAEFLARFGMKL-KV BbPmV1 NTLLALALLARRMRLAEKP---IDIAAMARSADGALLSYGDNQLIITSLFE-AHG--VEYDMD-DHAELLSEVGMRL-KK BdRV1 NDLLVLGHIADRAMTTLAMDEEAVAQQLARCAGGTLVSYGDNQLISEELFL-SLG--LTYDAD-AHAEFLSRFGMKL-KI CcFV1 NDMLAVSLLGSMVLDAGRDLDTVDVDDVARVVSNTLISYGDNQLIFEELFT-TFG--FSYTPA-RHAEHLRFFGMTL-KE FrPmV1 NDILALSLLAKMWMDAGNDLDDLDVDEVAAVAADSLISYGDNQLIFESLFA-TFG--LSYDVS-KHAEHLAVYGMRL-KI PdPmV1 NNLLVISLVIRRLMTEKGLTPRVARARVQAHVDGNLLSYGDNQIVGEELFI-AVG--LEYDAN-LHAEHLKRFGMKL-KV AspTmV1 NNLLVLGHLIDRAVRERGYTHAGAAGAVSGLVERFLRSYGDNQLFSEELFL-ALG--LAYDAD-KHAEFLARFGMTL-KV CcV1 NDLLALSLLGVTLMEQGVELSDVSPISVAQQASSDLVSYGDNQLIFDSLFS-RFG--VSYSLE-RHEAHLAAFGMKL-KV MoPmV1 NNLLILGHIVDRAANETEYTCAGAAEVLRHNLKGRLASYGDNQLFSEYLFK-ILG--MRYDPA-KHAEYLARYGMKL-KI PbTmV1 NDMLAIAVLVRALSRAGHA---IDVDAIARSASLNLISYGDNQLIIDELFT-EFG--LSYDAN-DHADLLARVGMKL-KI BbPmV2 NNLLLIAHIVDRAVSERGYTPAGAAEELRHIIKDRLLSYGDNQLFSTVLFK-ALG--LVYDPD-KHAEFLARYGMKL-KV SstRV1 NDLLAIGLLVRTMLDAGHT---VDVDECAATVSRWLLSYGDNQLFSTAMFR-EMG--VSYDKE-KHAAFLATLGMKL-KL PmTMV1 NNLLLLSHMIERVVRETSYTAEGAADELLDAADGLFISYGDNQLFSERILK-HFG--LRYDKE-KHVEFLARFGMTL-KA PjPmV1 NNLLVISLVIKRLMVEKGLSPRVARARVQPHIDGRLLSYGDNQIVSEELFI-AVG--LTYDPV-VHASHLACFGMTL-KI CCV HMLYFCMALNISARGACLP-----PLQ-NPILDCELATYGDDCIYKFPTLY-Q-----GA-FG-NFIQALRTLGLKPTAP EBHSV HWLLWSAAVYKA-CDEIGL-----F-CSNLYEDAPFFVYGDDGVYAMTPMM-V-----SL-LP-AILDNLRDYGLSPTAA RHDV HWLLWSAAVYKS-CAEIGL-----H-CSNLYEDAPFYTYGDDGVYAMTPMM-V-----SL-LP-AIIENLRDYGLSPTAA FMCV HLIMVNHAMASHGYG----------PY-GSDDRVWFTSYGDDFVCGVRDPS-FL---DTL------RSVWSDFGFTATNA TCV HCIYFVSALWLTE-DGACI-----ARTRDPLVKNRIWTYGDDCIYALCPRS-A-----AN-AL-YFTESLKALGLQPTAP N1V HWILWSATVRKC-SL--PL-----H-IGSVNELAPFLTYGDDGLYTIPSHL-T-----KS-ID-EIISTLKGYGLSPTAP NV HWIITLCALSEATGLS--------PD--VVQSMSYFSFYGDDEIVSTDI---------DFDPA-RLTQILKEYGLKPTRP TV HWIASTIAIAYA-AK---------I-PIAEAVNWPLAVYGDDEVINCPCSN--------F-AV-RYANEMRRMGFHPTNP ASCV HLLTINDILLEHGAA----------PVGSMGCPLDFVSYGDDIVLAMDDVL-VA---DWL------VAGWKARGFAATNA SV HMIYVAAAILQA-YESHNV-----PYTGNVFQVETVHTYGDDCMYSVCPAT-A-----SI-FH-AVLANLTSYGLKPTAA SVCV HWIASAISLTNC-GY-----------DPSEAIRVPLLVYGDDEVIALKPE---------L-SA-AYFEHMRALGFCPTGP FCV HCLYVGCAILQS-LEAKAI-----PVTWNLFSTFDIMTYGDDGVYMFPIMY-A-----SI-SD-QIFGNLSSYGLKPTRV VESV HCLMVGSAVVKA-LEDSGV-----RVTWNIFDSMDLFTYGDDGVYIVPPLI-S-----SV-MP-KVFANLRQFGLKPTRT TAstV NVWLTVFELAYLFYKEHNR----LPTICEIKKHTDWICYGDDRLLAVDKRF-I----NSYDTAAVIAMYKDVFGMWV-KP ANV NEWLTAFEFGYQHLENHGI----IPTVRDYRANVDFLCYGDDRLLAFNPSF-V-----NYDPQVTIDMYKNIFGMWV-KP DAstV NCWLTNFELAYLHNKQKGR----LPTVKELRENSAFICYGDDRLLSVSEDF-V-----KYESDTIIKMYEEIFGMWV-KP HAstV NFWLQAFEFAYFNGP-----------DKDLWKTYDTVVYGDDRLSTTPSVP-D-----NYEE-RVITMYRDIFGMWV-KP FAstV NFWLQAFEFAYLNKG---------KDIEALWKEYDTIVYGDDRLSTTPCLP-D-----DYVP-RVVQMYKEVFGMWV-KP PAstV NFWLQAFEFAWINGP-----------NKELWKSYDTIVYGDDRLNTTPYVP-P-----NYEE-MIIGMYRDVFGMWV-KP BCV1 NYTMLATLLSALGFD----------P-K----HCIIKVQGDDSIIRLNVLV-PQDQHQNLMDN-LVQLAVNYFNAVV-NV CpCV1 NCIMIFTILDAMGFE----------I-T---SDLIIKVLGDDSLTRLRLLI-PYDQHEAFTIR-FKHLAQYYFDAVL-SD WCCV NYTMLATILSALHFD----------P-L----HCIIKVQGDDSILRLTTLI-PVDQHTNFMDH-IVRLADTYFNSIV-NV AhV NLTILLDGLIEFGFT----------D-E-EIKQLLVFIMGDDNVIFTPWTL-LKL--IEFFDW-FAKYTLDRFGMVI-NI CrV1 NLVVLIDSLFEFGFH----------E-S-DITSALILLMGDDNVVFAPDKL-SQL--HSFFLF-LPGYAKKRWNMTV-NV FpV1 NLFLLIDGLIEFGST----------D-A-EIDDILLFIMGDDNSAFTTWSI-THL--EQFVSF-FETYALSRYGMVL-SK CSpV1 NMIACQYASLRS-RDY-------------NLRIPFSCWLGDDSFLNFETALCRQE--FEY----DYLEKFKELGLNV-SI PCV1 NYLRINYLWRLL----------------TGHPPQQCHTLGDDSLVGDNS---------YVNPQ-AIEEAANKLGWHF-NP PCV2 NRLRVEYIFRKA----------------YDVGPKMCYTQGDDSLIGVDF---------RVDPD-RLSEIAAPLNWKL-NP AoV NDILVQYICLCQQVE-----------------PKDLRVLGDDSAFRSCADL-DLGQ---------AERDAKDVNMVL-HP DdV1 NNILIDYLADCQQLE-----------------IRNLKVLGDDSAFRSTDQF-DLEV---------AKDDCVPTGMVI-KP PsV-S NYILVDYLAACQQCE-----------------IRALRVLGDDSAFRSCDPF-SLDL---------ASHDAECVNMIL-HP : **: . HadV1 SETI----VS--------R--ELHH---V---------AYCSTKYVRLMGNNGLNGPFVP--VRPYNALMPKLFAN---- AfuTmV1 DETE----VT--------V--KLGR---V---------RFCSRSLVRTP-----HGL-LI--TRSHNSLFAKLAGR--PR BbPmV1 DETE----VS--------D--RLDR---I---------RFCSRAVVRTP-----AGM-AI--TRPHGDVVAKLVAR--PT BdRV1 EETK----VS--------P--WVGD---A---------RFCSRAAVQTP-----YGL-IV--TRPHTSIYQKLAGR--PR CcFV1 DETD----VS--------D--LVGR---V---------RFCSRGVVQTP-----KGL-AI--TRSHSSLYSKLGGR--PH FrPmV1 DETD----VS--------D--KLGR---V---------RFCSRSVISTP-----RGL-AI--TRSHTSIFSKIGGR--PH PdPmV1 DETE----VT--------R--KAGR---A---------RFCSRGCVTTP-----AGK-LL--MRTHTSMLTKVAGT--PE AspTmV1 EETE----VS--------T--RLCR---A---------RFCSRGAVRTP-----YGL-LV--MRSHDSLYAKLAGR--PE CcV1 DETG----VS--------S--QLGD---V---------RFCSRGALLTP-----HGL-AI--VRSHTSIFHKIGGR--AE MoPmV1 DETE----VT--------D--SIAR---V---------RFCSRAVVMTP-----HGP-LI--TRTHSSIAAKLAAR--PE PbTmV1 DETE----VT--------N--KLSR---V---------RFCSRAVIRTP-----LGL-VV--TRQHSDVVLKIAGR--PT BbPmV2 DETE----VT--------R--RLGR---V---------RFCSRGVVMTP-----HGP-II--TRTHTSLVSKLAAR--PE SstRV1 DETE----IT--------Q--QLGR---V---------RFCSRAVVRTP-----HGL-AV--TRSHDPLISKLAGR--PT PmTMV1 DETE----VT--------H--LLGR---V---------RFCSRAVVSTP-----EGL-LV--TRTHTSFAAKLAGR--PE PjPmV1 DETE----VS--------N--KLGR---A---------RFCSRACVQTP-----KGK-LL--LRTHTSLYGKIAGT--PD CCV DKTS----DI--------A--LGLR---I---------VYLKRELRDAE-----GNW-RDGPVLDLDSIVRQAYWVR--G EBHSV DKTE----F-----I-DVC--PLKD---I---------SFLKRKFVMSE-----LGW-LS--QLDRSSILRQLEWTK--T RHDV DKTE----F-----I-DVC--PLNK---I---------SFLKRTFELTD-----IGW-VS--KLDKSSILRQLEWSK--T FMCV SKTG----PP--------SLVGFHD---L---------RFLKRGFTTNK-----QGTWMA--PLDISSIEKSLRFT--RA TCV DKTQ----NY--------S--LDRD---I---------TFLKRDIVPLG-----NLV-VG--RLDLESILRQAVWVK--G N1V DKGA----NVEIKRT-SFT--YLSG---P---------VFLKRRIVLTP-----GGH-RA--LLDLTSLARQPVWVN--G NV DKTEGPIQVR--------K--NVDG---L---------VFLRRTISRDA-----AGF-QG--RLDRASIERQIFWTRGPN TV DKSE----FF------HPI--HKSK---M---------EFLSRTTQYVG-----GRC-VG--ALKKTSIERQLYLTR--G ASCV AKTG----AP--------RCTSLRE---T---------SFIKRSFRKVD-----G-EWRA--PLEEASIWKGLSWM---- SV DKSD----AI--------K--PTNT---P---------VFLKRTFTQTP-----HGV-RA--LLDITSITRQFYWLK--A SVCV DKGP----TI------HGV--KATA---M---------EFLSRRTRWEG-----GTY-VG--ALKEESIRRQLHLTR--G FCV DKSV----GA----I-EPI--DPDS---V---------VFLKRTITRTP-----QGI-RG--LLDRSSIIRQFYYIK--G VESV DKSD----AE----ITPIP--ADEP---V---------EFLKRTIVRTE-----NGV-RA--LLDRSSIIRQFYYIK--A TAstV DNIKV----F--------P--SLEG---V---------SFCGMVWTKRK-----GQY--V-GKPNVDKILSTLS------ ANV ENIKL----F--------D--SPTG---S---------SFCGFTLVKPH-----GQW--V-GVVNVNKLLQSL------- DAstV ENVKV----Q--------K--DPEG---L---------SFCGMTLVRNQ-----HGI-FV-GVPNVDKILSTLR------ HAstV GKVIC----R--------D--SIVG---L---------SFCGFTVNENL-----EPV----PT-SPEKLMAS-------- FAstV EKVKV----T--------D--TVKG---A---------SFCGFTVGDNY-----QPI----PS-NPDKLWASLV------ PAstV GKVKV----Q--------N--TIVG---L---------SFCGFTVNENL-----EPV----PT-QPEKLMAALLKP--YK BCV1 KKSE----FG--------N--SLNG---R---------EVLSYRNH--------NG-F-P--HRDEIMMLAQFYHT--KA CpCV1 KKSR----IH--------N--TLNG---V---------KCLGYRNN--------NG-L-P--VRDRESLLTALLYP--KA WCCV KKSE----VR--------N--SLNG---C---------EVLSYRNH--------NG-L-P--HRDEITMLAQFYHT--KA AhV SKSA----VT--------S--IRRK---I---------EVLGYTNN--------YG-F-P--TRSISKLVGQLAYP--ER CrV1 DKSI----FT--------T--LRRK---I---------EILGYTNN--------YG-M-P--VRSLSKLIGQLAYP--ER FpV1 TKSI----IT--------T--LRHK---I---------ETLSYQCN--------FG-H-P--RRPIGKLVAQLCFP--ER CSpV1 DKTHY----T--------TR--FIDDFEVRFKGIRPYVKFLGKQIDILD-----LT---F--HNDLDKLDAQMALP--EK PCV1 DKTQ----YS--------T--VPEE---I---------TFLGRTYVGG----------LN--KRDLTKCIRLLVYP--EY PCV2 AKTD----VS--------L--YPEH---V---------TFLGRTMYGG----------IN--QRDLKRCLRLLIFP--EF AoV EKCD----VK--------T--DPTK---M---------KLLGTTYR--------NG-H-A--HRDTDEWFKLVLYP--ES DdV1 EKCE----RT--------E--DPND---F---------KLLGTKYR--------DG-R-V--YRSTDEWFTLALYP--ES PsV-S EKCE----KT--------K--DPTA---F---------KLLGTTYR--------NG-R-P--HRETNEWFKLALYP--ES : HadV1 EVPDQLSAKLY---VRAL---MLDTLGVD--PVLFSYLSE-----------------------------------L-DQS AfuTmV1 --HDPVVDKLY---VRAM-MV--DHMGTD--PIVYAILNE-----------------------------------I-DRS BbPmV1 --ENSVDDKLY---VRAL-MA--DYMGVD--PIVHRILAD-----------------------------------V-DAT BdRV1 --HDPAIDKLY---VRAL-MM--DHMGTD--PIAFEIMDS-----------------------------------V-DSM CcFV1 --DDPLYNKLY---VRAL-MV--DLLGTD--PGLYRELAA-----------------------------------I-DEG FrPmV1 --DEPVYNKLY---LRAL-MV--DLLGTD--AAMYDALAR-----------------------------------L-DES PdPmV1 --LEPMTYKLW---LRAT-AI--DHMGAD--PIVYNFLKH-----------------------------------L-DSM AspTmV1 --HDPLIDKLY---VRAM-MV--DHMGTD--PIVFELLSD-----------------------------------I-DRS CcV1 --VDPVINKLY---VRAL-MV--DLLGTD--PILYHGLQH-----------------------------------L-EAS MoPmV1 --HDPVVDKLY---VRAL-MA--DTMGTD--PLLFEIMSR-----------------------------------V-DRS PbTmV1 --ANAMDDKFY---VRAL-MA--DYLGVD--PIVHDMLMK-----------------------------------I-DRT BbPmV2 --HDPLVDKLY---VRAI-MA--DHMGTD--PIAYEMLAT-----------------------------------V-DRQ SstRV1 --ASPLADKLY---VRAL-MM--DYLGTD--PIAYQMLEF-----------------------------------V-DRQ PmTMV1 --HDPTTDKLY---VRAL-MC--DTLGTD--PILFRALSS-----------------------------------I-DRA PjPmV1 --VEPMVFKLW---LRAT-AI--DHMGTD--PIVYNLLKR-----------------------------------I-DSM CCV --TAHRD------------------PREV--A-TRVHD---------------------------------------GRG EBHSV --AKRHM------------------CIEE--CSELDKD---------------------------------------ERG RHDV --TSRHM------------------VIEE--TYDLAKE---------------------------------------ERG FMCV PT---PY---L---CDGT-MRDH--LLLG--DAQYSRLQM-----------------------------------AFTEA TCV --GSNTD------------------HTVP--RLPVDIV---------------------------------------ARE N1V --PRRSV------------------WNHEAQPIEIDAE---------------------------------------TRT NV --HSDPSETLVPHTQRKIQLI--SLLGEA--------------------------------------------------- TV --PQHNN------------------PLEI----GFPGP---------------------------------------WFG ASCV -------------------------------------------------------------------------------- SV --NRTSD------------------PSS---PPAFDRQ---------------------------------------ARS SVCV --PKHTD------------------PTEV----RLPHA---------------------------------------EYV FCV --ENSDD------------------WKSP--PKHIDPT---------------------------------------SRG VESV --ENTEN------------------WTVP--PKRIDTP---------------------------------------SRG TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV ----------------------L--------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV --VLPDLESLH---GKLL---CY--------------------------------------------------------- BCV1 RD--PTPEITM---AQAI-GFAYASCANN--KRVLWALKD-----------------------------------V-YDY CpCV1 RR--PTFEQLK---ARCI-GIAYASAGND--PTTLEVCKD-----------------------------------V-YDY WCCV RD--PTPEITM---AQAI-GFAYASCANH--NRVLWVLED-----------------------------------V-YNY AhV HV---TDADMC---MRAI-GFAYASCAQS--ETFHALCKK-----------------------------------V-FQY CrV1 HG---FDSDMC---MRAI-GFAWCAAACD--STFHDFCRK-----------------------------------V-FMY FpV1 GP---RPKYMS---ARAV-GMAWASCGQD--KTFHDFCRD-----------------------------------V-YHE CSpV1 --EDLSAYETG---VRLI-GLVWAYGAHY--DIYLRILKVYLSLKLKPVFHVQQLLSYSEKPERTKRYLENFFSSM-KYQ PCV1 PVESGRISAYR---AKSI---AQDAGGLS--EVLNRIADK-----------------------------------L---- PCV2 PVPSGEISAYR---AVSI---AQDAGGTS--EILNSIAKR-----------------------------------L---- AoV SV--RSLEVSF---SRLI-GLWIGGAMFD--SAFCRFMEY-----------------------------------Y-QTC DdV1 SV--LTLDVSF---TRLV-GLWLGGAMWD--KQFCAFMDY-----------------------------------Y-QTS PsV-S VV--PSLQVSF---TRLI-GLWIGGAMFD--SRFCQFMEY-----------------------------------Y-QTC HadV1 LGEIDV-DKS-KVGKRKYGKMLRDI-VVKLFGEDDEDGMRE---IIEKSL-NSGFDR-----RTCL----SLLTVAPMDL AfuTmV1 L-NVSL-EAA-GL-TDAAKKVLEDT-AQSMFGNREQDALLA---VYRALS-ETVIDR-----RALL----SLHTPRDGD- BbPmV1 I-RVTI-DAV-RA-SERHRDTLRSA-ASQVFGRKDDDAIAA---TAQLMA-KAVIDR-----RVLL----ELTQPRSVND BdRV1 V-DVDL-STV-GL-TPAVRSVLTDA-AKSFYGDASDDSLSR---VLEALS-TSRVDR-----RALL----SLHTPRTGAE CcFV1 I-HVPP-DFV-VS-DAKVEKVVEPF-ARRFFGRSTPEAVSA---FVAILQSRGPPNR-----RTLL----SLSLPRKDRP FrPmV1 I-EFPL-DFV-VS-DAKVEAIVKPF-ARRFFGSEDPLAISN---FVEVIRGARPPSR-----RTIL----SLRLPRKDSE PdPmV1 V-QAPQ-GTV-SIKSRQVRDVLDNL-CQKFVGDTSEESMAI---ALGVLE-RGFPTR-----AALL----SLHTRLEKG- AspTmV1 L-NVNL-SGS-AL-TPAVRRVLEDT-ARSMFGDRGDESLMA---VLRAVS-GTTVDR-----RALL----SLHTPRVVG- CcV1 I-DVPG-DAR-LS-EHRLHKMVEPF-AKKLYGNSSPESVAS---FVSLLKSPSAPDR-----GVLL----SLRLPADA-P MoPmV1 I-DVPI-SLE-TI-TPRVKPVLASA-AKTLFGSDADEYMLS---VLHDLS-TTIIDR-----RALL----SLHTPAGAAT PbTmV1 I-AVQP-DAV-QG-SKRHRSTLESA-AMQIYNRKDDAAVMA---TAYLMS-SSDIDR-----RMLL----ELTSPKSAEE BbPmV2 I-DVPV-DIS-TV-TPRVKGVLSAA-SWSLYGTDSDEAMLV---VLRGLS-QSVVDR-----RALL----SLHTPRADHV SstRV1 I-VLRPGDAD-TI-PKQLKREVEET-AMHVFGSADATAIGA---VVAMVT-ATDVPR-----ADLL----LLHLPRVPGA PmTMV1 I-PVAL-DLE-TI-SRKTMPVISSA-AKSLLGTDDDWALSA---VLTSLT-SATIDR-----RALL----SLHTPRSTGE PjPmV1 V-RVTG-VPS-MK-TRAVRDVLENL-CQKFMGNTNDESMEI---ALSVLN-RSFPTR-----AALL----SLHTALAGG- CCV L-QLDL-ALA-AL-SQHGPEVFSQN-VHPFIR------------------------------------------------ EBHSV V-QLEE-LQI-HA-AAHGEEFFELV-KKELRRQQAFTRFSV--FDYQTAR-KTLGDR-----KRIV----SVV------- RHDV V-QLEE-LQV-AA-AAHGQEFFNFV-CRELERQQAYTQFSV--YSYDAAR-KILADR-----KRVV----SVV------- FMCV YQ---H-GEEYYNDLK------------------------------KRVI-KCAADK-----KFRL----F--------- TCV T-QIKE-ALL-AL-SLHGETVYEKW-LPLFKHTIDCEGL----------------------------------------- N1V I-QLQN-VLI-EL-AWHQPQDFDHV-LALVVKSAEASGLT--------------------------------I------- NV ----------------------------------------------------------------------SLHGEKFYRK TV E-QLMC-VMG-EA-SLHGEQYFNEI-KDKCARA-A--------------------------------------------- ASCV -------------------------------------------------------------------------------- SV A-QLEN-ALA-YA-SQHGPVVFDTV-RQIAIKTAQGEGLVLVNTNYDQAL-ATY-------------------------- SVCV T-QLHC-ALG-EA-SLHGRKFFHAF-CDEVAEAVR--------------------------------------------- FCV Q-QLWN-ACL-YA-SQHGLEFFNKV-YRLAERAVEYEELHFEPPTYASAL-DHYNSQ----------------------- VESV Q-QLYN-ACL-YA-SQHGEEFYTSKIVPLIERAVKLEGLHIEVPEFHQAV-AAYNGYFNGTEGQ-P----NQI------- TAstV -------------------------------------------------------------------------------- ANV -------------------------------------------------------------------------------- DAstV -------------------------------------------------------------------------------- HAstV -------------------------------------------------------------------------------- FAstV -------------------------------------------------------------------------------- PAstV -------------------------------------------------------------------------------- BCV1 YK---D-LGY--TPNR-------AG-LTLTFGDSPDLFVPE---ISLEHF-PTETEI-----RRYL---TSTSY------ CpCV1 LD---A-KGI--KADP-------AG-LADLFDP--N-LGLD---IDITFF-PNILTI-----QRSL---LIL-R------ WCCV YR---D-LGY--RPNR-------AG-LTLTFGDSPDLTMPE---MPLDHF-PTKSEI-----RRYH---TETHY------ AhV YF---A-KTS--INERLILKGRKAE-LPGMFFAYPD-VSEH---IRLDHF-PSLSEV-----RILL----S-KF------ CrV1 YY---A-RVN--VPIKDLVQANASA-LPGMFFAYRD-VHQH---IKLDHF-PSIEEV-----RQVL----S-KH------ FpV1 FN---D-DRA--DLDESAYLHIQSH-LPGYLKIDES-VRQI---VDFQVF-PSQQTV-----YHTV----S-RW------ CSpV1 LN-LDL-DIY-DL--LTFPKF-WDV-SNRYFGSKYER------------------------------------------- PCV1 ---------------------------RRIYGTASEEEVPI---YFKRYV-F---------------------------- PCV2 ---------------------------RRQYGVAEEHAVPK---HFKLYI------------------------------ AoV FQ---C-P--------------------------------------EDGW-FSK-EQ-----RRWLEVVYGNRAP----- DdV1 YP---V-P--------------------------------------EEGW-FSK-DQ-----KRWLEVVYSGKAP----- PsV-S FP---C-P--------------------------------------QEGW-FSK-DQ-----RRWLQVVYGGKAP----- HadV1 ETQIQ----AKYKMSGEFGLGLSIGEYNLGFARTDE-VFRKLEKFNIESY------V-NFLVDTGQKDVLLDLDDISKM AfuTmV1 ------------HDPGRLHTSVSTGMHLFTGEL-TP-AAQWAYECTVEKW-------CQYLHDTDQEGVMFD------- BbPmV1 VDSVLERTGKVTGVRFRQRFAASVGIQTDVPSL-VG-PAAWLASQDEQQY-------LDYLVRTDQVGVMH-------- BdRV1 ------------GSVAKLGHAPQLGGPLLTNVL-TP-AAEWVAELGPKQW-------IEYLERTGQMGVLTDE------ CcFV1 -----------EDAPRRFGSDLVLGAS-REEDL-DE-VGKWLAAQDYEAY-------TKYLRDTGQLDVLVGN------ FrPmV1 ------------GRVYRYGTDLVLDSR-CDAPL-DE-VGEWLIRKTPNEY-------MRFLAETDQREVLIGN------ PdPmV1 ------------AKDKRLGMALFFDDGKTGFDL-TP-AAQWALDQTEESW-------LEYLRKTDQMGLLVD------- AspTmV1 ------------DSTPRLGSSVTTGLDLFVGSL-TP-AAQWAYEMTPGEW-------CRYLEETGQEEVMYD------- CcV1 ------------GALKRFGTGLTLGSGKATTGL-DD-VGRWLLDLSPADY-------WKYVNDTGQTSIIYNN------ MoPmV1 ------------KREMRTGTSLGVGVSLFGGPL-TP-AATWALSLTPDAW-------VAYLTETGQLEVMYDKSD---- PbTmV1 PEAIVARGDRQRRNSTRLRSSLTVGYRHREPLL-SG-PAVWLAEIGPQEY-------LNYLVETDQVGVIA-------- BbPmV2 ------------RSDMRLGTSVSLGDTLFGGPL-TD-AARFCLGHTPATW-------ITFLKDTGQEGVMIE------- SstRV1 A-------------FGDVFGMGVRGGRVFRGAG-TE-MTRWLAEQTPDQW-------FEFLTRSGQLGVLEP------- PmTMV1 ------------SRGERLGSGLTIGGKLFGGPI-TA-AADWASSQTPESY-------FSHLASTNQTGVLID------- PjPmV1 ------------MAHGKLGTALLFDDGARGFEL-TP-AAQWALDQTEDSW-------LEYLRSTDQMGVLTD------- CCV ------------------------------------------------------------------------------- EBHSV -------------------------------------------------------------PDDSFVNVME-------- RHDV -------------------------------------------------------------PDDEFVNVME-------- FMCV ---------------------------------------------FI--I------P-TFKQFRIR------------- TCV ------------------------------------------------------------------------------- N1V -------------------------------------------------------------PRYSQ---EEAR------ NV ------------ISSKVIHEIKTGGLEMYVPGW-QA-MFRWMRFHDLGLWTGDRDLLPEFVNDDGV------------- TV ------------------------------------------------------------------------------- ASCV ------------------------------------------------------------------------------- SV ------------------------------------------------------------------------N------ SVCV ------------------------------------------------------------------------------- FCV ------------------------------------------------------------------------------- VESV ---------------------------------------------------------AHASGGLGLSGEVFEN------ TAstV ------------------------------------------------------------------------------- ANV ------------------------------------------------------------------------------- DAstV ------------------------------------------------------------------------------- HAstV ------------------------------------------------------------------------------- FAstV ------------------------------------------------------------------------------- PAstV ------------------------------------------------------------------------------- BCV1 -----------------------------LNEAQ-N-ARTWPRTLFIN-A------P-AQ------------------- CpCV1 -----------------------------DSREQ-A-HRMWPTSHFLS-P------IPGL-VDI--------------- WCCV -----------------------------QNEAQ-N-ARTWPRTLFIN-A------P-GE------------------- AhV -----------------------------QGYLK-E-TPFGTIPTFS--T------P-QTLRDQTQ------------- CrV1 -----------------------------HGYLT-E-EPLWKYDFFI--H------P-KP------------------- FpV1 -----------------------------KGPLS-Y-QPEMGSCSLC--Q------P-T-------------------- CSpV1 ---------------L-----------------------DF--------------------R-SH---KIYG------- PCV1 -------------------------------------------------------------------GV---------- PCV2 --------------------------------------------------------------------P---------- AoV -----------------------------RGWSA-KKSLFWRSIFYA--Y------A---------------------- DdV1 -----------------------------RGWTT-KRSLFWRSIFYA--F------G---------------------- PsV-S -----------------------------RGWTT-KRSLFWRSIFYV--Y------G----------------------